This record was last updated January 26, 2026 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this study is to evaluate the effects of transauricular vagus and trigeminal nerve stimulation on the treatment of pain in children with Sickle Cell Disease.
* The primary objective is to determine the feasibility of using a tAN device to treat pain in pediatric participants with SCD by assessing the completion rate, stimulation tolerability, and acceptability of the intervention measures.
* The secondary objective is to assess the preliminary efficacy of using a tAN device as a remedy for pain in pediatric SCD subjects by analyzing inflammatory serum biomarker levels, the Functional Status Scale (FSS), the Wong-Baker FACES questionnaire, tracking analgesic consumption, and other assessments.
Protocol Amendment History
3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-07-21; most recent amendment 2026-01-23.