Clinical Trial

Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.

Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated July 28, 2025 (before its estimated February 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
The aim of the current study is to evaluate the effects of resveratrol on the clinical outcome(s) of patients with moderate rheumatoid arthritis. Objectives : 1. To investigate the effects of Resveratrol on inflammation and oxidative stress by measuring: * Serum Sirtuin 1(SIRT1) * Serum Myeloperoxidase (MPO) * Serum C-reactive protein (CRP) 2. To investigate the effects of Resveratrol on disease activity by measuring the disease activity (DAS28 score). 3. To investigate the effect of Resveratrol on improving the quality of life using the Health Assessment Questionnaire Disability index (HAQ-DI). 4. To assess any adverse effects related to Resveratrol. Patients: Eligible patients (no=118) will be randomly assigned in a 1:1 ratio to one of two groups: 1. Control group: 59 patients will receive the standard treatment for management of RA for 3 months. 2. Resveratrol group: 59 patients will receive the standard treatment for management of RA in addition to Resveratrol 1 gm daily, (Organix Egypt) (given as one 1000 mg tablets once daily) for 3 months.
Trial Details
NCT Number NCT07089381
Lead Sponsor Ain Shams University
Conditions Rheumatic Arthritis, Rheumatoid Arthritis (RA) Prevention, Inflamation, Antioxidant, Anti Oxidative Stress, Anti Aging, C Reactive Protein, Methotrexate +1 more
Enrollment 118 participants
Start Date 2025-08-01
Primary Completion 2026-02-01 (estimated)
Study Completion 2026-06-01 (estimated)
Updated on ClinicalTrials.gov 2025-07-28