Clinical Trial

Single Step Protocol and Multi-step Warming Protocol for Blastocyst FET

Study acronym: ONESTEP
Recruiting
View on ClinicalTrials.gov →
Summary
The multi-step thawing protocol with a reduction of non-permeable cryoprotectant concentrations to reduce osmotic shock caused by the rapid influx of water. Recent studies have shown that a simplified warming protocol by only a thawing solution gave a comparable survival rate but increased pregnancy rate, reduced patients' waiting time, and decreased the workload of embryologists.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-07-20; most recent amendment 2025-09-10.
Status change: Not Yet Recruiting → Recruiting 2025-08-18
Trial Details
NCT Number NCT07088640
Lead Sponsor Mỹ Đức Hospital
Conditions IVF, Frozen Embryo Transfer (FET), Embryo Thawing Protocol
Enrollment 816 participants
Start Date 2025-08-13
Primary Completion 2026-12-31 (estimated)
Study Completion 2027-03-01 (estimated)
Updated on ClinicalTrials.gov 2025-09-12