Feasibility of HPV Testing With Mail-delivered Sample Collection Kits

People living with human immunodeficiency virus (PLWH) have an estimated 1.6-6.0 times increased risk of developing oropharyngeal cancer (OPC) compared with individuals in the general population. 70% of OPCs are caused by human papillomavirus (HPV), and PLWH also have an increased prevalence of oral HPV infection. Disparities by race/ethnicity also include a later stage of diagnosis and less frequent cancer-directed treatment for members of ethnic minority groups. There is little known regarding the racial/ethnic differences in oral HPV infection, persistence of oral HPV infection, or progression of oral HPV infection to OPC among PLWH. This is an observational, prospective cohort study to investigate the feasibility of alternative sample collection methods for HPV testing among PLWH.

NCT Number	NCT07087145
Lead Sponsor	University of California, San Francisco Collaborators: National Institute of Dental and Craniofacial Research (NIDCR)
Conditions	HPV Infection, HIV Infections, HPV-Related Malignancy
Enrollment	135 participants
Start Date	2024-11-17
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-08-01