The Self-Sampling Pilot Study

The investigators will test the cytological performance of a nylon-flocked swab at two insertion depths in the anus, 3 cm and 5 cm, to determine which insertion depth is better at collecting cells from the squamocolumnar junction (SCJ), an anatomic site that is particularly vulnerable to carcinogenic transformation. The investigators hypothesize that the 5 cm insertion will result in a higher quality specimen with cells from the SCJ. However, the deeper swab insertion may affect end user acceptability without increasing adequacy or quality.

NCT Number	NCT07085845
Lead Sponsor	Medical College of Wisconsin
Conditions	Squamous Cell Carcinoma of the Anus
Enrollment	50 participants
Start Date	2025-07-31
Primary Completion	2025-09-12 (estimated)
Study Completion	2025-09-12 (estimated)
Updated on ClinicalTrials.gov	2026-01-27