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Comparison of Outcomes of Management of Bowel Obstruction

Study acronym: COMBO
StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study sites: 3 to 4 Start date changed from estimate of Feb 2026 to Feb 3, 2026v3 Show 1 more changeShow less
    • Start date changed from estimate of Feb 2026 to Feb 3, 2026
  2. Trial status: Not Yet Recruiting to Recruiting Start date: Dec 2025 to Feb 2026 · Primary endpoint revised · Study sites: 0 to 3 · 2 morev2 Show 5 more changesShow less
    • Start date: Dec 2025 to Feb 2026
    • Primary endpoint revised
    • Study sites: 0 to 3
    • Secondary endpoints revised (3)
    • Eligibility criteria expanded, about 4 words

    See this version in full on ClinicalTrials.gov ↗

  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.
Trial Details
NCT Number NCT07084441
Lead Sponsor University of Washington
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions Adhesive Small Bowel Obstruction
Enrollment 550 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov