Clinical Trial

Comparison of Outcomes of Management of Bowel Obstruction

Study acronym: COMBO
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-07-16; most recent amendment 2026-05-05.
Status change: Not Yet Recruiting → Recruiting 2026-02-17
Trial Details
NCT Number NCT07084441
Lead Sponsor University of Washington
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions Adhesive Small Bowel Obstruction
Enrollment 550 participants
Start Date 2026-02-03
Primary Completion 2030-06 (estimated)
Study Completion 2030-12 (estimated)
Updated on ClinicalTrials.gov 2026-05-07