Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait

This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators estimate enrolling 50 female volunteers who are at least 50 years old and have not had a menstrual period for at least 12 consecutive months. Volunteers need not know whether they have SCT as this will be evaluated as part of the study.

NCT Number	NCT07083531
Lead Sponsor	UConn Health
Conditions	Sickle Cell Disease, Sickle Cell Trait
Enrollment	50 participants
Start Date	2022-08-23
Primary Completion	2025-08-23 (estimated)
Study Completion	2025-08-23 (estimated)
Updated on ClinicalTrials.gov	2025-07-24