Abutment Hydrophilicity on Soft Tissue Morphogenesis

The goal of this clinical trial is to evaluate the effect of abutment surface bioactivation via argon plasma treatment on peri-implant soft tissue healing and integration in adult patients undergoing implant therapy. The main questions it aims to answer are: Does argon plasma treatment of healing abutments improve the quality and organization of peri-implant connective tissue compared to untreated abutments? Does the treatment influence histological parameters such as epithelial regeneration, vascularization, inflammatory infiltrate, and keratin layer thickness? Researchers will compare plasma-treated healing abutments to untreated machined-surface abutments to determine whether the bioactivated surface improves soft tissue morphogenesis. Participants will: Undergo implant placement with immediate connection of either a treated or untreated healing abutment. Have plaque and bleeding indices recorded at 3 months. Undergo a soft tissue biopsy at 3 months for histological analysis (including evaluation of inflammation, connective tissue, epithelial morphology, vascularization, and keratinization).

NCT Number	NCT07082088
Lead Sponsor	Paolo Pesce
Conditions	Missing Tooth/Teeth
Enrollment	40 participants
Start Date	2025-07-31
Primary Completion	2025-10-30 (estimated)
Study Completion	2025-10-30 (estimated)
Updated on ClinicalTrials.gov	2025-07-24