Clinical Trial

A Temporal Variability Study of Remimazolam for General Anesthesia Induction and Maintenance

Active, Not Recruiting
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Record status
This record was last updated July 23, 2025 (before its estimated June 20, 2026 completion). Its status may not reflect the trial's current state.
Summary
The purpose of this study was to observe and compare the differences in plasma concentration, dosage and carboxylesterase 1 activity of remimazolam when remimazolam is used for general anesthesia induction and maintenance at different times of the day, and to explore the effect of time rhythm on the pharmacokinetics and pharmacodynamics of remimazolam, so as to provide new ideas and clinical basis for optimizing medication regimens and anesthesia management.
Trial Details
NCT Number NCT07079800
Lead Sponsor Jie Chen
Conditions Biological Rhythm, Drug Metabolism and Pharmacokinetics
Enrollment 188 participants
Start Date 2025-06-17
Primary Completion 2026-06-20 (estimated)
Study Completion 2026-07-20 (estimated)
Updated on ClinicalTrials.gov 2025-07-23