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Adhesion Prevention in ASBO Surgery Using 4DryField® PH

Study acronym: ADHERE
StatusNot Yet Recruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated July 22, 2025 (before its estimated July 15, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Study First Submitted
Post-surgical adhesions occur in up to 90% of abdominal surgeries, often leading to complications like adhesive small bowel obstruction (ASBO) and chronic pain. They result from imbalanced healing processes influenced by growth factors, fibroblast activity, and genetic predispositions. While surgery can relieve ASBO, it frequently causes new adhesions, with recurrence rates up to 40%. Anti-adhesion barriers, such as the starch-based 4DryField® PH, form a temporary gel barrier to support healing. Though promising, its role in preventing ASBO recurrence is not well studied. This study evaluates whether intra-operative use of 4DryField® PH reduces ASBO recurrence over 12 months and compares perioperative outcomes in treated vs. untreated patients.
Trial Details
NCT Number NCT07078981
Lead Sponsor Alessio Giordano
Collaborators: PlantTec Medical GmbH
Conditions
(from sponsor)		 Adhesive Small Bowel Obstruction, Postoperative Abdominal Adhesions, Bowel Obstruction, Abdominal Surgery Complications
Related terms Abdomen, Acute, Bites and Stings, Intestinal Obstruction, Tissue Adhesions
Enrollment 189 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov