Clinical Trial

Discovery of HPV T Cell Epitopes and Development of Multi-epitope Vaccines

Not Yet Recruiting
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Summary
Based on the trend that the incidence and mortality of cervical carcinoma among female cancers worldwide are increasing year by year, the investigators aim to develop a multi-epitope therapeutic vaccine capable of simultaneously activating humoral and cellular immune responses, which is achieved by fusing multiple T-cell epitope immunostimulatory proteins. To obtain information on functional T-cell epitopes to be included in the vaccine, the investigators conducted research starting from clinical cases. By collecting peripheral blood and cancerous tissues from clinical patients, the investigators isolated reactive T-cells and screened for information on T-cell epitopes of HPV antigens.
Trial Details
NCT Number NCT07077980
Lead Sponsor Anhui Provincial Hospital
Conditions Cervical Cancer
Enrollment 50 participants
Start Date 2025-09-01
Primary Completion 2028-07-01 (estimated)
Study Completion 2033-09-01 (estimated)
Updated on ClinicalTrials.gov 2025-07-22