Natriuresis-guided Depletion After Cardiac Surgery

Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical. Recent data suggest that natriuresis-guided furosemide titration using point-of-care urinary sodium sensors (LAQUAtwin NA-11, Horiba) may improve the efficiency and safety of fluid removal, but no randomized trial has yet evaluated this approach in postoperative cardiac surgery patients Our goal is to assess the clinical impact, safety, and feasibility of a natriuresis-guided furosemide protocol after cardiac surgery requiring cardiopulmonary bypass.

NCT Number	NCT07077772
Lead Sponsor	Centre Hospitalier Universitaire, Amiens
Conditions	Cardiac Surgery, Diuresis, Congestion, Venous, Sodium Depletion, Fluid Over-load
Enrollment	102 participants
Start Date	2025-06-25
Primary Completion	2027-10 (estimated)
Study Completion	2027-10 (estimated)
Updated on ClinicalTrials.gov	2026-01-21