Clinical Trial

Topical Icariin on Acne and Acne Scars

Completed
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Summary
The goal of this clinical trial is to examine whether topical application of icariin can improve acne and atrophic acne scars in adults. The main questions it aims to answer are: * Does icariin reduce the number of facial acne lesions and acne scars? * What histological changes occur in acne or scar tissue after using icariin? Researchers will compare icariin to a vehicle control (3% ethanol solution) to assess its relative efficacy. Participants will: * Apply icariin or control solution to each side of the face twice daily for 2 months * Visit the clinic every 4 weeks for checkup * Receive skin biopsies before and after the study period, if they consent to this procedure
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-07-17.
Status change: Active, Not Recruiting → Completed 2026-03-04
Trial Details
NCT Number NCT07076784
Lead Sponsor Seoul National University Hospital
Conditions Acne, Acne Scars
Enrollment 25 participants
Start Date 2023-03-21
Primary Completion 2025-12-31 (estimated)
Study Completion 2025-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-03-05