Uptake and Excretion of a Single Dose of Oral 14C-labelled Polystyrene Microplastics in Healthy Volunteers

The goal of this clinical trial is to understand how a small, labeled dose of microplastics moves through the human body (i.e., how it is absorbed, distributed, and excreted) in healthy adult volunteers aged 18-65 years (3 males, 3 females). The main questions it aims to answer are: * How much of the ingested microplastic is absorbed into the bloodstream? * How is the microplastic distributed and eliminated from the body through urine and feces? Participants will: * Take a single oral micro dose of 100 µg of 1 μm \[14C\]-labelled polystyrene microplastics (PS-MP). * Spend 24 hours in a clinical research facility for close monitoring and initial sample collection. * Provide blood, urine, and stool samples over a 5-day period (with daily short lab visits after the first day). This study does not include a comparison group.

NCT Number	NCT07075991
Lead Sponsor	Wageningen University Collaborators: ZonMw: The Netherlands Organisation for Health Research and Development, TNO
Conditions	Kinetics
Enrollment	6 participants
Start Date	2025-06-19
Primary Completion	2025-08-31 (estimated)
Study Completion	2025-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-20