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National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial

Study acronym: NC-CHRM
StatusNot Yet Recruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

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  1. Start date: Oct 15, 2025 to Jan 2028v2 Show 5 more changesShow less
    • Primary and study completion dates: Jun 30, 2031 to Dec 2031
    • Eligibility criteria expanded, about 25 words
    • Secondary endpoints revised (5)
    • Study description expanded, about 230 words
    • Study title shortened, about 3 words
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Liver disease deaths are rising, but transplants remain scarce in India. With over 100,000 needed annually and only \~2,500 performed, non-transplant options are urgently needed. Regenerative therapy, especially mesenchymal stem cells (MSCs), shows promise but lacks validation, particularly for non-viral ACLF. The proposed NC-CHRM aims to develop and validate MSC-based therapy to promote native liver regeneration and offer a safe, effective, transplant-free treatment.
Trial Details
NCT Number NCT07075315
Lead Sponsor Institute of Liver and Biliary Sciences, India
Collaborators: Indian Council of Medical Research
Conditions
(from sponsor)		 Acute-On-Chronic Liver Failure
Related terms Acute-On-Chronic Liver Failure
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov