Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit

The goal of this prospective observational study is to evaluate whether right ventricular (RV) function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success in adult intensive care unit (ICU) patients who are mechanically ventilated. The main questions it aims to answer are: Can the TAPSE (Tricuspid Annular Plane Systolic Excursion) value predict successful extubation? Do other right heart parameters (tricuspid S', RV-FAC, right atrial area, pulmonary valve acceleration time) provide additional prognostic value for weaning outcomes? Participants will: Be adult ICU patients planned for weaning from mechanical ventilation. Undergo transthoracic echocardiography within 2 hours after meeting clinical weaning criteria. Have the following echocardiographic parameters measured: TAPSE, tricuspid S', RV-FAC, right atrial area, and pulmonary valve acceleration time. Be monitored for 24 hours after extubation to assess weaning success (defined as no need for reintubation, non-invasive ventilation, or high-flow oxygen support).

NCT Number	NCT07073976
Lead Sponsor	Kanuni Sultan Suleyman Training and Research Hospital
Conditions	Weaning Failure of Mechanical Ventilation
Enrollment	60 participants
Start Date	2025-07-31
Primary Completion	2026-07-15 (estimated)
Study Completion	2026-07-16 (estimated)
Updated on ClinicalTrials.gov	2025-09-09