Effect of Exercise on Muscle Activity, Strength, and Balance in People With Knee Osteoarthritis

This will be a clinical trial of a standardized group exercise intervention, Les Mills Thrive, and determine if it alters muscle activation patterns and improves strength, balance, and symptoms in those with knee osteoarthritis (OA). Muscle activation patterns will be assessed using surface electromyography, strength will be assessed using isokinetic dynamometry, balance will be measured using the Community Balance and Mobility Scale (CB\&M), and symptoms and typical activity will be measured using two questionnaires: the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Physical Activity Scale for the Elderly (PASE). These outcome measures will be measured at baseline and after a 12-week group exercise intervention (Les Mills Thrive) for 42 older adults with knee OA. Results of this study will be disseminated via a report to Les Mills International, in community presentations, at relevant academic (e.g. Osteoarthritis Research Society International (OARSI) annual conference) and industry (e.g. Medical Fitness Association annual meeting) conferences, in an academic journal publication (e.g. Arthritis Care \& Research), and through press releases or other media publications.

NCT Number	NCT07073911
Lead Sponsor	Gillian Hatfield Collaborators: Les Mills International
Conditions	Osteo Arthritis Knee and Hip
Enrollment	42 participants
Start Date	2025-08-26
Primary Completion	2026-06-19 (estimated)
Study Completion	2026-06-19 (estimated)
Updated on ClinicalTrials.gov	2026-05-01