Clinical Trial

Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation

Study acronym: ProCog
Recruiting
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Record status
This record was last updated March 31, 2026 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
This 12-week, double-blind, placebo-controlled trial will examine whether daily supplementation with the Lab4P probiotic can improve cognitive performance and metabolic health in overweight adults aged 18 to 40 with impaired glucose tolerance, a preclinical condition where blood glucose regulation is mildly disrupted. Seventy participants will be randomly assigned to receive either Lab4P or a placebo. The study will assess changes in memory, executive function, and processing speed, along with blood glucose control, cardiovascular function, cholesterol levels, body composition, and markers of inflammation. The study will also analyse changes in the gut microbiome and evaluate the safety and tolerability of the probiotic.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-07-09; most recent amendment 2026-03-25.
Status change: Active, Not Recruiting → Recruiting 2025-09-01
Status change: Not Yet Recruiting → Active, Not Recruiting 2025-08-15
Trial Details
NCT Number NCT07073781
Lead Sponsor Leeds Beckett University
Collaborators: Cultech Ltd, Port Talbot, UK
Conditions Impaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes), Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Overweight (BMI > 25), Cognitive Dysfunction, Neurovascular Coupling Mechanism and Cognitive Function
Enrollment 70 participants
Start Date 2025-08-15
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-08-20 (estimated)
Updated on ClinicalTrials.gov 2026-03-31