Glymphatic Function and White Matter Integrity in Cerebral Venous Disorders

Cerebral venous disorders, including cerebral venous sinus stenosis (CVSS) and cerebral venous sinus thrombosis (CVST), can obstruct venous blood drainage, leading to intracranial hypertension. However, their effects on glymphatic function and white matter integrity in the brain remain poorly understood. Therefore, this study will enroll healthy controls, CVSS patients, and CVST patients to compare differences in glymphatic function and white matter microstructural integrity. Additionally, CVSS and CVST patients will undergo a 3-month follow-up to investigate the interrelationships and longitudinal changes among clinical parameters, glymphatic function, and white matter integrity.

NCT Number	NCT07072663
Lead Sponsor	Xuanwu Hospital, Beijing
Conditions	Cerebral Venous Sinus Thrombosis
Enrollment	149 participants
Start Date	2025-07
Primary Completion	2026-07 (estimated)
Study Completion	2026-10 (estimated)
Updated on ClinicalTrials.gov	2025-07-18