Chitosan and i-PRF in Palatal Wound Healing

This study aims to evaluate the effects of chitosan and injectable platelet-rich fibrin (i-PRF) on wound healing at the donor site following free gingival graft (FGG) procedures. The palatal donor area often experiences delayed healing and postoperative discomfort, motivating the search for effective biomaterials to enhance recovery and reduce patient morbidity. Although various approaches have been investigated, the combined application of chitosan and i-PRF has not yet been explored in this context. The study examines three patient groups treated at the periodontology departments of Çukurova and Biruni University: one with gelatin sponge (control), one with chitosan, and one with chitosan infused with i-PRF. Parameters such as pain (VAS), bleeding, burning sensation, dietary changes, epithelialization (PEHI score), and color match were assessed over a 2-month follow-up. The findings are expected to provide insights into whether i-PRF-enhanced chitosan offers superior healing outcomes and greater patient comfort compared to conventional methods.

NCT Number	NCT07072546
Lead Sponsor	Biruni University Collaborators: Cukurova University
Conditions	Free Gingival Graft, Wound Healing, i-PRF, Chitosan
Enrollment	68 participants
Start Date	2025-07-12
Primary Completion	2025-12-10 (estimated)
Study Completion	2025-12-10 (estimated)
Updated on ClinicalTrials.gov	2026-01-27