Trametinib Treatment for Complicated Vascular Anomalies

Complicated vascular anomalies have diverse etiologies and variable clinical manifestations, and no standardized treatment protocol has been established. Since most patients present with diffuse lesions that are difficult to resect surgically, identifying effective therapeutic strategies is of critical importance. This study aims to evaluate the safety and efficacy of systemic trametinib therapy in patients with complicated vascular anomalies.

NCT Number	NCT07072403
Lead Sponsor	West China Hospital
Conditions	Vascular Anomalies
Enrollment	20 participants
Start Date	2025-07-07
Primary Completion	2027-07-01 (estimated)
Study Completion	2027-09-01 (estimated)
Updated on ClinicalTrials.gov	2025-07-22