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Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder

Study acronym: WAIT-AYA
StatusRecruiting
PhaseNot applicable
Started
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Record status
This record was last updated February 18, 2026 (before its estimated August 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary and study completion dates: Mar 2026 to Aug 2026v3 Show 4 more changesShow less
    • Interventions: Alcohol-specific inhibition training (Other), Control training (Other) to Control training (Other), Substance-specific inhibition training (Other)
    • Secondary endpoints: details revised at 3 of 4 entries
    • Eligibility criteria expanded, about 3 words
    • Study title expanded, about 2 words
  2. Start date changed from estimate of Jul 2025 to Jul 23, 2025
    • Secondary endpoints: details revised at 2 of 4 entries
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Substance misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide. Although there are effective treatments for substance use disorder (SUD), there is still a need to further improve their effectiveness and make them easier to access. Early research suggests that substance-specific inhibition training, when used in addition to specialized treatment, can improve treatment outcomes. This training aims to strengthen inhibition specifically in situations with substance-related cues. The goal of this project is to offer this training for the first time in the form of a smartphone app, which is expected to increase the availability of the training. The main aim of the study is to evaluate whether this new app-based cognitive training is feasible as an add-on to the treatment of SUD in adolescents and young adults. In addition, the study will gather preliminary insights into whether the training affects drinking behavior and related brain processes. The project will be conducted as a double-blind, clinical pilot study. A total of 210 adolescents and young adults between 14 and 35 years old will be recruited from five specialized treatment centers. After the first study visit, participants will be randomly assigned to one of two groups: (1) an intervention group receiving the alcohol-specific inhibition training or (2) a control group receiving a similar alcohol-nonspecific inhibition training. During their participation, all participants will complete six short training sessions with the app. About one month later, they will complete six additional booster training sessions. This research may help develop effective, easily accessible tools to support young people with substance use disorder.
Trial Details
NCT Number NCT07071779
Lead Sponsor University of Bern
Conditions
(from sponsor)		 Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD), Substance Use Disorder (SUD)
Related terms Alcoholism, Substance-Related Disorders
Enrollment 210 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov