Cough Management Wellness App for Refractory or Unexplained Chronic Cough

The goal of this single-cohort clinical trial is to learn whether a smartphone-based Cough Management (CM) program can reduce cough frequency and burden in adults (21-80 years) who have refractory or unexplained chronic cough.  The main questions it aims to answer are: * Does four weeks of using the CM feature in the CoughPro app lower objective cough rate (coughs per hour) compared with each participant's one-week baseline?  * Does the program also lessen cough intensity (bout metrics) and improve patient-reported quality-of-life scores on the Leicester Cough Questionnaire and PGI-S? Participants will: * Wear a Hyfe CoughMonitor smartwatch continuously for 6 weeks (1-week baseline, 4-week intervention, 1-week follow-up), charging it nightly.  * Complete science-based in-app CM lessons based on behavioral cough-suppression therapy and practice the techniques during the 4-week intervention. * Fill out online questionnaires (LCQ and PGI-S) at baseline and at the end of Week 4. * Join a brief exit interview, then return the smartwatch and receive a compensation voucher.

NCT Number	NCT07070895
Lead Sponsor	Hyfe Inc
Conditions	Refractory Chronic Cough, Unexplained Chronic Cough, Cough Hypersensitivity
Enrollment	20 participants
Start Date	2025-03-27
Primary Completion	2025-08-08 (estimated)
Study Completion	2025-09 (estimated)
Updated on ClinicalTrials.gov	2025-09-11