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Impact of Aorto-Iliac Occlusive Disease Treatment on Blood Pressure

StatusRecruiting
PhaseNot applicable
Started2026-03-30
View on ClinicalTrials.gov ↗

Amendment history

2026-03-30
critical
Study Status, Contacts/Locations v2
Recruitment opened
Primary completion pushed: 2027-04-30 → 2027-12-31
Start dateestimated 2026-01-15→confirmed 2026-03-30
Study sites0→1
2026-01-05
minor
Study Status v1
Start date2025-10-01→2026-01-15
2025-07-16
minor
Original filing
Hypertension is a major risk factor for a variety of cardiovascular diseases. When hypertension results from increased vascular resistance due to a narrowing of the descending aorta, it can be effectively treated with stenting. More recently, evidence suggest that stenting in more distal parts of the arterial vascular bed is also associated with a reduction in blood pressure. The investigators hypothesize that stenting of occlusions more distal of the descending aorta decreases the central blood pressure and afterload as reflected by NT-proBNP (N-terminal pro-Brain Natriuretic Peptide), a biomarker of intracardiac pressures and predictor of heart failure events. The goal of this pilot study is to prospectively investigate changes in blood pressure after stent placement in the aorto-iliac region.
Trial Details
NCT Number NCT07070583
Lead Sponsor Rijnstate Hospital
Conditions Aorto Iliac Occlusive Disease, Blood Pressure
Enrollment 20 participants
Start Date 2026-03-30
Primary Completion 2027-12-31 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-03