Longitudinal Cohort Study on Immune Thrombocytopenia Complicated With Acute Ischemic Stroke

Immune thrombocytopenia (ITP) is an acquired bleeding disorder mediated by immune-related platelet destruction and impaired platelet production. Immune thrombocytopenia may increase the risk of cerebral infarction and represents a relatively uncommon etiology of acute ischemic stroke. This disease is associated with high disability and mortality rates, poses significant therapeutic challenges, and constitutes a serious threat to human health. Therefore, research on the diagnosis, treatment, and prognosis of ITP combined with acute ischemic stroke is of great significance for improving patients' quality of life and survival outcomes. However, most current hematologic cohort studies are based on single-center or limited multicenter sample sizes, lacking comprehensive and large-scale prospective cohort studies. Our center plans to conduct a large-sample, combined retrospective and prospective longitudinal cohort study. This study will register patients' basic information and diagnosis, follow up with patients through questionnaires, telephone calls, video consultations, online platforms, and in-person visits to record treatment and comorbidity data, collect prognostic information, and retrieve hospitalization and outpatient costs through medical record systems. The study aims to provide comprehensive data on the incidence, treatment, prognosis, and healthcare costs of ITP patients with acute ischemic stroke in China.

NCT Number	NCT07070193
Lead Sponsor	Peking University People's Hospital Collaborators: Jiangsu province hospital of TCM, Army Medical University, China, Henan Cancer Hospital, The Affiliated People's Hospital of Ningbo University, West China Hospital, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, First Affiliated Hospital of Zhejiang University, The Second Hospital of Hebei Medical University, Kunming Medical University Second Affiliated Hospital, Shanghai Zhongshan Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Huazhong Science & Technology Shanxi Baiqiu En Hospital, NORTHERN JIANGSU PEOPLE'S HOSPITAL 1900, Tongji Hospital, Xuzhou Medical University Affiliated Hospital of Huaian, Affiliated Hospital of Fujian Medical University, Xiehe Branch, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, First Affiliated Hospital of Guangxi Medical University, The Third Xiangya Hospital of Central South University, Second Xiangya Hospital of Central South University, Xiangya Hospital of Central South University, Qilu Hospital of Shandong University, Southern Medical University, China, The First Affiliated Hospital of University of Science and Technology of China, The First Affiliated Hospital of Nanchang University, First Affiliated Hospital of Xinjiang Medical University, North China University of Science and Technology
Conditions	Immune Thrombocytopenia (ITP), Acute Ischemic Stroke
Enrollment	500 participants
Start Date	2025-07-10
Primary Completion	2035-12-31 (estimated)
Study Completion	2036-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-07-17