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Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

Study acronym: SYNCHRONICITY
StatusRecruiting
PhaseNot applicable
Started2025-10-22
View on ClinicalTrials.gov ↗

Amendment history

2026-09-03
Study Status, Contacts/Locations v15
Study sites38→40
2026-08-03
Study Status, Contacts/Locations v14
Trial sites expanded: 35 → 38 locations
2026-07-01
Study Status, Contacts/Locations v13
Trial sites expanded: 32 → 35 locations
2026-06-03
Study Status, Contacts/Locations v12
Trial sites expanded: 29 → 32 locations
2026-05-04
Study Status, Contacts/Locations v11
Trial sites expanded: 23 → 29 locations
2026-04-02
Study Status, Contacts/Locations v10
Trial sites expanded: 18 → 23 locations
2026-03-04
Study Status, Contacts/Locations v9
Study sites12→18
2026-02-04
Study Status, Contacts/Locations v8
Study sites6→12
2026-01-05
Study Status, Contacts/Locations v7
Study sites3→6
2025-12-04
Study Status, Contacts/Locations v6
Study sites2→3
2025-11-05
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v5
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2025-10→confirmed 2025-10-22
Study sites0→2
2025-10-02
Study Status v4
Re-verified, no change to tracked fields
2025-09-16
Study Status, Eligibility v3
Eligibility criteria+1 characters
[...] stigator provides justification (e.g., contraindicated, not toleranttolerated or cost): Renin Angiotensin System Inhibitors (ACE, ARB, or [...]
2025-09-05
2 amendments v1-v2
2 re-verifications since 2025-08-04, no change to tracked fields
2025-07-07
Original filing
This study will compare two different methods to pace the heart to treat heart failure including: 1. The current standard method of implanting a pacing lead in a vein on the surface of the left lower chamber of the heart (left ventricle) to deliver heart failure therapy. This method is called Cardiac Resynchronization Therapy (CRT). 2. The other method is using a lead implanted in the Left Bundle Branch Area (LBBA) of your heart. This method is called Left Bundle Branch Area Pacing or LBBAP. This lead is approved by the Food and Drug Administration (FDA) to be implanted in this area of the heart, but not to provide heart failure treatment.
Trial Details
NCT Number NCT07069738
Lead Sponsor Boston Scientific Corporation
Conditions Heart Failure - NYHA II - IV
Enrollment 850 participants
Start Date 2025-10-22
Primary Completion 2029-11 (estimated)
Study Completion 2029-11 (estimated)
Updated on ClinicalTrials.gov 2026-09-04