Clinical Trial

Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

Study acronym: SYNCHRONICITY
Recruiting
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Summary
This study will compare two different methods to pace the heart to treat heart failure including: 1. The current standard method of implanting a pacing lead in a vein on the surface of the left lower chamber of the heart (left ventricle) to deliver heart failure therapy. This method is called Cardiac Resynchronization Therapy (CRT). 2. The other method is using a lead implanted in the Left Bundle Branch Area (LBBA) of your heart. This method is called Left Bundle Branch Area Pacing or LBBAP. This lead is approved by the Food and Drug Administration (FDA) to be implanted in this area of the heart, but not to provide heart failure treatment.
Protocol Amendment History 5 changes
notable Trial sites expanded: 35 -> 38 locations 2026-08-05
notable Trial sites expanded: 32 -> 35 locations 2026-07-03
notable Trial sites expanded: 29 -> 32 locations 2026-06-05
notable Trial sites expanded: 23 -> 29 locations 2026-05-06
notable Trial sites expanded: 18 -> 23 locations 2026-04-04
Trial Details
NCT Number NCT07069738
Lead Sponsor Boston Scientific Corporation
Conditions Heart Failure - NYHA II - IV
Enrollment 850 participants
Start Date 2025-10-22
Primary Completion 2029-11 (estimated)
Study Completion 2029-11 (estimated)
Updated on ClinicalTrials.gov 2026-08-04