Clinical Trial

Effect of Bio-activation on Epithelial and Connective Cell Adhesion to Titanium Abutments: Split Mouth Clinical Trial

Not Yet Recruiting
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Record status
This record was last updated July 16, 2025 (before its estimated October 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
The aim of this "in vivo" controlled trial is to assess soft tissue cell adhesion to titanium abutments subjected to different cleaning procedures - no treatment (as they come from the industry), and cleaning by plasma- at an early healing time. In fact, the primary aim is Quantity and Quality of soft tissue adhesion at the microscopic level (e.g Fibronectin, Integrin-actin). The secondary Aim - Clinical parameters and outcomes - BOP, PPD, MBL (Marginal Bone Level to check influence of plasmapp-treated abutments). The null hypothesis of the study was that the cleaning procedure applied to implant abutments has no effect on soft tissue cell adhesion and MBL at an early healing time.
Trial Details
NCT Number NCT07069231
Lead Sponsor Universita degli Studi di Genova
Conditions Missing Tooth/Teeth
Enrollment 20 participants
Start Date 2025-07-15
Primary Completion 2025-10-30 (estimated)
Study Completion 2025-10-30 (estimated)
Updated on ClinicalTrials.gov 2025-07-16