Upfront Ultrasound for Preoperative Localization in Primary Hyperparathyroidism

Primary hyperparathyroidism is caused by overactive parathyroid glands, leading to elevated calcium levels in the blood. The standard preoperative imaging includes both a radiation-based imaging modality and conventional ultrasound. However, ultrasound alone is a faster, safer, and more patient-friendly alternative. This study evaluates an upfront ultrasound approach, where patients undergo ultrasound first, and only those with certain findings proceed directly to surgery without additional imaging. Patients with uncertain findings proceed to additional imaging. The study is designed as a prospective cohort with a non-inferiority analysis, aiming to confirm whether upfront ultrasound can achieve an acceptable diagnostic sensitivity. If successful, this approach could reduce patient burden, minimize radiation exposure, and optimize healthcare resources

NCT Number	NCT07068867
Lead Sponsor	Odense University Hospital
Conditions	Primary Hyperparathyroidism
Enrollment	99 participants
Start Date	2023-09-01
Primary Completion	2025-09-18 (estimated)
Study Completion	2025-09-18 (estimated)
Updated on ClinicalTrials.gov	2026-01-14