Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys

Cerebral small vessel disease (cSVD) is characterized by an alteration of the structure and function of small penetrating brain arteries. Highly prevalent in older individuals from the general population, it represents a leading cause of stroke and a major contributor to cognitive decline and risk of dementia. Better detection and management of covert cSVD would have a major impact on preventing disability and costs related to stroke, cognitive impairment and dementia. The aim of the present study is to identify novel electroencephalographic (EEG) biomarkers of the cognitive deficits associated with cSVD, and how these biomarkers and cognitive performance are affected by personalized cognitive training or transcranial alternating current stimulation (tACS), a non-invasvie brain stimulation technique.

NCT Number	NCT07068620
Lead Sponsor	University Hospital, Bordeaux
Conditions	Cerebral Small Vessel Disease, Stroke, Cognitive Complaint
Enrollment	80 participants
Start Date	2025-08-07
Primary Completion	2028-03-07 (estimated)
Study Completion	2028-03-07 (estimated)
Updated on ClinicalTrials.gov	2026-02-02