Clinical Trial

Cefazolin Antibiotic Prophylaxis in Ventricular Shunt Surgery: Determination of Cerebrospinal Fluid Concentration During Valve Implantation

Study acronym: CC -PIV
Not Yet Recruiting
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Record status
This record was last updated August 8, 2025 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin. Our main hypothesis is that the concentration is insufficient to protect the valve from infections. The secondary objective is to compare our results to known pharmacokinetic models of cefazolin diffusion in the literature. If differences are found we would like to search clinical features that could explain it.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-07-15.
Trial Details
NCT Number NCT07067736
Lead Sponsor University Hospital, Strasbourg, France
Conditions Hydrocephaly, CSF Shunts, Antibiotic Prophylaxis
Enrollment 15 participants
Start Date 2025-08-01
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-08-30 (estimated)
Updated on ClinicalTrials.gov 2025-08-08