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Respiratory Strategies in COPD Patients With Persistent Hypercapnia Following Exacerbation

Study acronym: RESPHYC
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study First Submitted
This multicenter, cross-over study aims to investigate the effects of two different respiratory strategies, the use of high flow nasal cannula (NHF) and the use of home mechanic ventilation (HMV), both associated with standard oxygen therapy, in patients with COPD and persistent hypercapnia following a severe acute exacerbation. The purpose is to evaluate whether the clinical benefits, in terms of reduction in PaCO2 levels, resulting from the use of NHF are non-inferior to those obtained from the use of HMV. Partecipants will be randomized at 1:1 ratio into two groups: group 1: will start the respiratory strategy under study (NHF + standard oxygen therapy) as first treatment group 2 will start the control respiratory strategy (HMV + standard oxygen therapy) as first treatment. The study has a crossover design: each patient will undergo treatment with the two different respiratory strategies, NHF and HMV, each lasting for 3 months
Trial Details
NCT Number NCT07065799
Lead Sponsor IRCCS Azienda Ospedaliero-Universitaria di Bologna
Collaborators: Azienda Sanitaria dell'Alto Adige, Ospedale San Donato, Azienda Unita Sanitaria Locale di Piacenza, Policlinico Universitario, Catania, Fondazione Salvatore Maugeri
Conditions
(from sponsor)		 COPD, Hypercapnia, Exacerbation Copd
Related terms Hypercapnia, Pulmonary Disease, Chronic Obstructive
Enrollment 31 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov