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Effects of Frontopolar TMS in Alcohol Craving

Study acronym: TMS-SUD
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary endpoint revised Secondary endpoints: 7 to 8 · Study description shortened, about 19 words · Study title shortened, about 1 wordv2 Show 3 more changesShow less
    • Secondary endpoints: 7 to 8
    • Study description shortened, about 19 words
    • Study title shortened, about 1 word

    See this version in full on ClinicalTrials.gov ↗

  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this interventional study is to learn if continuous theta burst stimulation (cTBS) applied over the left frontopolar cortex can reduce psychological, physiological, and neurobiological markers of alcohol craving in patients with alcohol dependence (AD). The main questions it aims to answer are: * Does cTBS over the left frontopolar cortex reduce psychological and physiological measures of alcohol craving in individuals with AD? * Are baseline structural and functional brain connectivity patterns associated with individual differences in cTBS-induced changes in craving? The participants will: * Receive cTBS over the left frontopolar cortex using an accelerated protocol comprising 15 TMS-sessions on five consecutive days * Undergo psychological and physiological assessments of alcohol craving before and after the TMS intervention * Complete magnetic resonance imaging (MRI) sessions to assess baseline brain structural and functional connectivity This study aims to advance the understanding of the neurophysiological mechanisms underlying craving in AD and the identification of potential biomarkers for predicting psychological and physiological craving reductions.
Trial Details
NCT Number NCT07064590
Lead Sponsor Goethe University
Conditions Alcohol Addiction
Enrollment 34 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov