Clinical Trial

Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）

Not Yet Recruiting Phase 4
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Record status
This record was last updated July 14, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
This national, multi-center, randomized controlled study, through the study of intravenous injection of estaketamine in elderly patients undergoing surgery, is expected to explore whether estaketamine can improve the acute postoperative pain of elderly patients undergoing surgery and reduce the incidence of postoperative depression and delirium.
Trial Details
NCT Number NCT07063108
Lead Sponsor Chinese PLA General Hospital
Conditions Postoperative Pain
Enrollment 276 participants
Start Date 2025-12-01
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-07-14