Effect of Aerobic Exercise on Biomarkers in Depression

This study aims to investigate changes in the levels of biomarkers (IGF-1, FGF2, and EGF) involved in neuron development in patients diagnosed with major depression through the effects of breathing exercises and aerobic exercise, as well as to examine the levels of biomarkers (TNF-α, IL-6, and IL-1) and oxidative stress (TAS, TOS, MDA, and F2-isoprostane) that are thought to play a role in the pathophysiology of depression.

NCT Number	NCT07062783
Lead Sponsor	Kutahya Health Sciences University Collaborators: Kutahya Health Sciences University Scientific Research Projects Coordination Unit
Conditions	Major Depression
Enrollment	40 participants
Start Date	2024-08-01
Primary Completion	2025-08-31 (estimated)
Study Completion	2025-09-30 (estimated)
Updated on ClinicalTrials.gov	2026-08-05