Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT07059988 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Endogenous Energy Production in Critically Ill Patients

Study acronym: eEPIC
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 12 months later Dec 2026 → Dec 31, 2027
See other at-risk trials from Karolinska University Hospital

Record History

  1. Primary completion pushed from Dec 2026 to Dec 31, 2027v2 Show 4 more changesShow less
    • Recruitment opened
    • Study completion pushed from May 2027 to Jan 2028
    • Start date changed from estimate of Jul 2025 to Jul 14, 2025
    • Site details revised
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The aim of this study is to investigate when critically ill patients transition from a non-suppressible catabolism to a normal response to feeding. Endogenous production of glucose, fat and protein will be studied on a minimum of two occasions in mechanically ventilated ICU patients, in a fasted state and during parenteral nutrition. Substrate kinetics are estimated by a tracer dilution method using infusions of isotopically labeled glucose, glycerol and phenylalanine. Blood sampling for metabolomics analysis will be performed to elucidate potential biomarkers indicating an anabolic response to nutrition.
Trial Details
NCT Number NCT07059988
Lead Sponsor Karolinska University Hospital
Conditions
(from sponsor)		 Critical Illness, Metabolism and Nutrition Disorder
Related terms Critical Illness, Nutrition Disorders
Enrollment 40 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov