Effect of Different Root Canal Sealers on Oxidative Stress Markers

The goal of this clinical trial is to primary purpose investigate and compare oxidative stress markers in patients with chronic apical periodontitis treated with different root canal paste in a single session. The main questions it aims to answer are: Is there a change in oxidative stress markers measured from saliva after root canal treatment? Is there a difference between the change of oxidative stress markers in patients using different root canal sealers after root canal treatment? Researchers will compare bioceramic-based and epoxy resin-based root canal sealers to see if there are significant differences in oxidative stress markers measured from patients' saliva after root canal treatment. * Participants will be informed about all procedures before starting the clinical process. * Participants are expected to allow saliva sampling two times: first sample will be collected on root canal treatment session and second sample will be collected on the 30th day after root canal treatment. * Participants will be informed in writing about the treatment procedure before starting the clinical process. * Participants are expected to sign the informed consent form on a voluntary basis.

NCT Number	NCT07059481
Lead Sponsor	bengi gülgü
Conditions	Oxidative Stress, Chronic Apical Periodontitis
Enrollment	40 participants
Start Date	2024-03-18
Primary Completion	2025-09-02 (estimated)
Study Completion	2025-11-13 (estimated)
Updated on ClinicalTrials.gov	2025-07-10