Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty

This study is conducted to evaluate the effectiveness and safety of ketamine infusion for pain relief after knee replacement surgery. Adult patients who have undergone knee arthroplasty will be randomly assigned to one of two groups. The study group will receive standard pain management plus a continuous infusion of ketamine using patient-controlled analgesia (PCA), while the control group will only receive standard pain management. All patients will be monitored for pain intensity using the Numeric Rating Scale (NRS) at several time points the first 24 hours after surgery. The study will compare the total amount of opioid pain medication required, the level of pain experienced, and the frequency and severity of side effects such as nausea, vomiting, and neuropsychiatric reactions. The goal is to determine whether adding ketamine to standard pain management reduces opioid use and improves pain control without increasing side effects. The results improve pain management strategies after knee replacement surgery.

NCT Number	NCT07059429
Lead Sponsor	State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Conditions	Knee Arthroplasty, Postoperative Pain, Pain Management, Analgesia, Opioid Use, Ketamine
Enrollment	100 participants
Start Date	2025-07-01
Primary Completion	2025-12-31 (estimated)
Study Completion	2026-01-07 (estimated)
Updated on ClinicalTrials.gov	2026-03-02