Atrioventricular Nodal Ablation Versus Pulmonary Vein Isolation - Patient Centred Decisions

The goal of this clinical trial is to compare two procedural approaches to managing atrial fibrillation. The main questions it aims to answer are: Is AF ablation or pacemaker implant and AV nodal ablation a more effective treatment approach for patients with atrial fibrillation refractory to pharmacological treatment? What effect do these differing treatment approaches have on patient's quality of life and mental health? Participants will: Be randomly allocated to one of the treatment approaches. Visit the clinic 2 months, 12 months and 24 months after their procedure for a checkup, questionnaires and repeat heart ultrasounds.

NCT Number	NCT07059208
Lead Sponsor	Sunshine Coast Hospital and Health Service
Conditions	Atrial Fibrillation (AF)
Enrollment	172 participants
Start Date	2025-09
Primary Completion	2029-09 (estimated)
Study Completion	2031-09 (estimated)
Updated on ClinicalTrials.gov	2025-07-14