Disrupted Connections: The Impact of Acute Stress on Memory Integration

The goal of this study is to better understand how stress impacts people's ability to learn across their experiences and link new information to what they already know. The investigators will compare performance on a memory task between stressed and non-stressed participants. This memory task requires people to integrate knowledge across learning experiences (think: having to "connect the dots", draw inferences, and generalize your knowledge to new situations and scenarios). Cortisol, the brain's primary stress hormone, will be measured at multiple points throughout the study to measure stress levels. The investigators hypothesize that: 1. Stress will disrupt performance on the memory task by interfering with memory processes that enable linking of related memories. 2. Higher cortisol levels, which reflect a greater stress response, will relate to greater deficits in memory performance across participants. This research has broad implications for understanding how stress impacts the ability to learn and retain new information, particularly in high-stress environments like schools and workplaces. Additionally, this work may provide insights into the cognitive difficulties experienced by individuals with psychiatric disorders, where stress can worsen memory and learning challenges.

NCT Number	NCT07055555
Lead Sponsor	Nevada State University Collaborators: National Institute of General Medical Sciences (NIGMS), University of Nevada, Reno
Conditions	Stress, Control Condition
Enrollment	80 participants
Start Date	2026-03-26
Primary Completion	2027-05-07 (estimated)
Study Completion	2027-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-08