Clinical Trial

UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF

Study acronym: UPBEAT
Recruiting
View on ClinicalTrials.gov →
Summary
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systolic volume index by MRI.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2025-06-27; most recent amendment 2026-07-02.
Status change: Not Yet Recruiting → Recruiting 2025-08-14
Trial Details
NCT Number NCT07054489
Lead Sponsor David Lanfear
Conditions Heart Failure, Polygenic Score
Enrollment 10 participants
Start Date 2026-03-30
Primary Completion 2027-06 (estimated)
Study Completion 2027-06 (estimated)
Updated on ClinicalTrials.gov 2026-07-07