HCMR Re-Imaging Study

This study aims to learn what might predict heart problems (like sudden death from a fast heart rhythm or heart failure) in people with a genetic condition called hypertrophic cardiomyopathy (HCM). HCM causes the heart muscle to become thick, which can make the heart stiff and harder to work properly. It can also affect the heart's electrical system. This study is looking to enroll patients that were previously part of a research project called "HCMR - Novel Predictors of Outcome in Hypertrophic Cardiomyopathy." The results of that study are still being reviewed, but they might show that people who had a substance called Gadolinium (MRI contrast or dye) collected in their heart muscle may have a higher risk for heart problems, including sudden cardiac death. This is called "late gadolinium enhancement" (LGE). This study is aiming to do follow-up imaging on those patients to better understand how LGE affects people with HCM.

NCT Number	NCT07054073
Lead Sponsor	Christopher Kramer Collaborators: Brigham and Women's Hospital, Mayo Clinic, Tufts Medical Center, Northwestern University, University of Michigan, The Cleveland Clinic, University Hospital Birmingham NHS Foundation Trust, Glenfield Hospital, Leicester, London Chest Hospital, Cytokinetics, Toronto General Hospital
Conditions	Hypertrophic Cardiomyopathy (HCM)
Enrollment	314 participants
Start Date	2026-03-30
Primary Completion	2027-03 (estimated)
Study Completion	2027-07 (estimated)
Updated on ClinicalTrials.gov	2026-03-18