Investigation of a New Window Into Intracranial Pressure: Venous Occlusion Pressure of the Isolated Periorbital Vein

Elevated intracranial pressure (ICP) occurs when pressure inside the skull rises above normal levels, potentially leading to brain damage or herniation. Monitoring ICP is critical for managing conditions like brain tumors, traumatic brain injury, and stroke. Current ICP monitoring methods are invasive and carry risks, including infection and brain damage. For less severe cases, lumbar puncture is a safer, less invasive alternative. This study explores the potential of a non-invasive method, using venous pressure near the eye, to estimate ICP. The goal is to assess whether the results from this non-invasive approach are similar to the invasive lumbar CSF pressure measurements.

NCT Number	NCT07053631
Lead Sponsor	University of Freiburg
Conditions	Indication for CSF Dynamic Testing, Indication for CSF Infusion Test
Enrollment	10 participants
Start Date	2025-04-07
Primary Completion	2025-12-06 (estimated)
Study Completion	2025-12-08 (estimated)
Updated on ClinicalTrials.gov	2025-07-08