Clinical Trial

IV Dexamethasone in Preventing Post Spinal Hypotension

Active, Not Recruiting Phase 4
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Record status
This record was last updated July 31, 2025 (before its estimated August 5, 2025 completion). Its status may not reflect the trial's current state.
Summary
Orthopedic lower limb procedures are carried out under spinal anesthesia which involves administration of drugs in the space surrounding the spinal cord. From there the drug acts on the spinal cord blocking electrical signals moving across nerve fibers thereby providing sufficient pain relief and surgical conditions. However blocking of these fibers result in reduce signal transmission to blood vessels and heart resulting in fall in blood pressure. Various drugs can be used to treat or prevent this hypotension. One such drug is Dexamethasone which is a steroid. This drug can be administered before spinal anesthesia through Intravenous route to prevent fall in blood pressure.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-06-29.
Trial Details
NCT Number NCT07052864
Lead Sponsor Pakistan Institute of Medical Sciences
Conditions Hypotension During Surgery
Enrollment 134 participants
Start Date 2025-06-30
Primary Completion 2025-08-05 (estimated)
Study Completion 2025-08-05 (estimated)
Updated on ClinicalTrials.gov 2025-07-31