Comparative Evaluation of Hydrophilic and Hydrophobic Sealants in Partially Erupted First Molars

This randomized controlled clinical trial aims to evaluate and compare the retention, caries prevention, microleakage, and fluoride release of three types of pit and fissure sealants-hydrophilic, nanofilled hydrophobic, and conventional hydrophobic-applied to partially erupted first permanent molars in children aged 5 to 7 years. The study uses a split-mouth design and includes both clinical and laboratory evaluations over an 18-month period. Outcomes will assess sealant effectiveness with and without the use of a bonding agent.

NCT Number	NCT07052526
Lead Sponsor	Mansoura University
Conditions	Dental Caries
Enrollment	150 participants
Start Date	2025-07-01
Primary Completion	2027-01-01 (estimated)
Study Completion	2027-04-01 (estimated)
Updated on ClinicalTrials.gov	2025-07-09