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Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy

Study acronym: NOTICE-1
StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Recruitment opened
    • Start date changed from estimate of Feb 1, 2026 to Jul 22, 2026
    • Study sites: 1 to 2
    v4
  2. Primary completion date: Sep 30, 2027 to Mar 30, 2028v3 Show 7 more changesShow less
    • Start date: Oct 1, 2025 to Feb 1, 2026
    • Primary endpoint revised
    • Study completion date: Dec 31, 2027 to Mar 30, 2028
    • Interventions: High-flow oxygen therapy (Other), Hyperbaric Oxygen Therapy (Other) to Conventional therapy group (Other), Hyperbaric Oxygen Therapy (Other)
    • Eligibility criteria expanded, about 35 words
    • Secondary endpoints: 8 to 7
    • Study title shortened, about 6 words
  3. Start date: Jul 1, 2025 to Oct 1, 2025v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment 2. The main questions it aims to answer is: Whether HBO can improve the prognosis of ischemic stroke patients after endovascular treatment? 3. Participants will: receive HBO (1.6 Atmosphere Absolute，1.6ATA)，Once a day, for 1 hour each time, for 5 days a week (it can be non-consecutive days), the total course of treatment is 10 times. undergo three scheduled face to face or telephone follow-up assessments during the 12-month period following HBO.
Trial Details
NCT Number NCT07049692
Lead Sponsor Beijing Chao Yang Hospital
Conditions
(from sponsor)		 Acute Ischemic Stroke
Related terms Ischemic Stroke
Enrollment 424 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov