Clinical Trial

Perioperative Intravenous Nimodipine Trial

Recruiting
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Record status
This record was last updated July 2, 2025 (before its estimated May 19, 2026 completion). Its status may not reflect the trial's current state.
Summary
The role of perioperative IV administration of nimodipine, an L-type calcium channel antagonist which is capable of crossing the blood-brain barrier, on peri-operative opioid and anesthetics requirements, pain intensity, opioid-related side effects and early postoperative bowel mobility in patients undergoing surgical treatment for bowel cancer with open radical colectomy remains scarcely explored. A prospective double-blind, randomized controlled trial investigating the effect of perioperative IV administration of nimodipine in patients undergoing open colectomy for cancer treatment is therefore conducted.
Trial Details
NCT Number NCT07048522
Lead Sponsor University of Ioannina
Conditions Colectomy, Open Surgery, Pain, Pain, Postoperative, Pain, Acute
Enrollment 40 participants
Start Date 2025-05-19
Primary Completion 2026-05-19 (estimated)
Study Completion 2027-02-15 (estimated)
Updated on ClinicalTrials.gov 2025-07-02