Clinical Trial

Methoxyflurane for IUD Insertion and Endometrial Biopsy

Recruiting
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Record status
This record was last updated July 30, 2025 (before its estimated December 1, 2025 completion). Its status may not reflect the trial's current state.
Summary
The aim of this study is to determine if 3ml of inhaled Methoxyflurane, in the form of a Penthrox inhaler, reduces pain during IUD insertion and/or endometrial biopsy. The proposed study is a double-blind, placebo-controlled RCT. Each participant will be randomly assigned to one of two arms: 1. Intervention (3ml of Methoxyflurane via a Penthrox inhaler) 2. Placebo (3ml of normal saline via an identical placebo Penthrox inhaler) The primary outcome is global pain score, which will be patient-reported by the 100 mm Visual Analogue Scale (VAS) 5-minutes following the procedure (endometrial biopsy or IUD insertion).
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-06-27.
Trial Details
NCT Number NCT07046572
Lead Sponsor Mount Sinai Hospital, Canada
Collaborators: Matthew Morton Research Award
Conditions Endometrial Biopsy, Intrauterine Devices
Enrollment 174 participants
Start Date 2025-07-24
Primary Completion 2025-12-01 (estimated)
Study Completion 2026-03-01 (estimated)
Updated on ClinicalTrials.gov 2025-07-30