Reduction in Resistance Training Volume and Neuromuscular Adaptations in Older Adults

The goal of this clinical trial is to evaluate how reducing resistance training volume affects neuromuscular adaptations in older adults aged 60 to 70 years. The main questions it aims to answer are: Can strength and muscle adaptations be maintained with lower training volume? Does reducing training volume influence muscle power and hypertrophy in older adults? Researchers will compare two groups: A group that reduces training volume in one or both legs A group that maintains the same training volume in both legs to see if reducing volume leads to different neuromuscular outcomes. Participants will: Complete an initial 10-week strength training program (2x/week) using unilateral leg press and knee extension machines, performing 3 sets per exercise Undergo tests for muscle strength (1-RM), muscle thickness (ultrasound), and power (isokinetic dynamometry) at weeks 0, 5, and 10 After 10 weeks, be randomly assigned to: A reduced-volume group: one leg does 2 sets and the other 1 set per exercise Or a control group: both legs continue doing 3 sets Continue training for another 10 weeks under the assigned protocol Repeat strength, muscle thickness, and power assessments at weeks 5 and 10 of phase 2 Attend a dietary intake interview with a registered dietitian This study will help determine the minimum effective training volume needed to maintain strength and muscle health in older adults, potentially improving long-term adherence to exercise programs.

NCT Number	NCT07046130
Lead Sponsor	University of Sao Paulo
Conditions	Sarcopenia in Elderly, Dynapenia
Enrollment	45 participants
Start Date	2025-05-29
Primary Completion	2025-12-18 (estimated)
Study Completion	2026-12-18 (estimated)
Updated on ClinicalTrials.gov	2025-07-01