Temporal Pole Transcranial Alternating Current Stimulation for Children With Autism Spectrum Disorder

The goal of this open-label randomized controlledl trial is to explore the safety and efficacy of conventional transcranial alternating current stimulation (tACS) and transcranial temporal interference stimulation (tTIS) targeting the temporal pole in children with autism spectrum disorder (ASD) in China. The main questions it aims to answer are: \*Can tACS and tTIS safely and effectively improve clinical symptoms in children with autism? Researchers will compare the tACS group and tTIS group with control group to explore the safety, feasibility and efficacy of the transcranial electrical stimulation in children with autism. Participants will: * tACS group: undergo 5 days of temporal pole tACS * tTIS group:undergo 5 days of temporal pole tTIS * Control group: receive routine rehabilitation training during the study period. From baseline to 4 weeks after intervention completion, subjects will be followed up regarding clinical symptoms and adverse reactions: * Safety Outcome Measures: adverse events * Primary Efficacy Outcome Measures: Social Responsiveness Scale (SRS-2) total scores * Other clinical outcome measures related language, adapative function and cognition

NCT Number	NCT07045584
Lead Sponsor	Fei Li
Conditions	Autism Spectrum Disorder
Enrollment	36 participants
Start Date	2025-07-01
Primary Completion	2025-09-30 (estimated)
Study Completion	2025-10-07 (estimated)
Updated on ClinicalTrials.gov	2026-03-25