Betadine vs Sterile Water for Periurethral Preparation

The purpose of this study is to determine whether cleaning of the urethra, or external opening to the bladder, with sterile water (water that has been treated to remove bacteria and living organisms) vs Betadine also known as Povidone-Iodine (a medical grade cleaning solution) changes the rates of bacteria in the urine after a temporary catheter, or draining tube, is placed into the bladder. Chemical antiseptics, including Betadine, are the current standard of care. An additional goal of this study is to determine whether cleaning of the urethra, or external opening to the bladder, with sterile water vs betadine changes the amount of discomfort or pain patients experience with placement of a temporary catheter, or draining tube, in the bladder.

NCT Number	NCT07044726
Lead Sponsor	University of Louisville
Conditions	Catherization, Urinary Tract Infection Bacterial
Enrollment	148 participants
Start Date	2025-06-30
Primary Completion	2028-05-21 (estimated)
Study Completion	2028-05-21 (estimated)
Updated on ClinicalTrials.gov	2026-05-04